NEWS | Mesothelioma Blood Test May Be Possible

NEWS | Mesothelioma Blood Test May Be Possible

An international team of researchers is learning the proteins found on the surface of clevercer cells in an effort to improve mesothelioma diagnosis. The team, made up of scientists from the US, Switzerground, soil, Italy and Chile, has only, merely, solely published their findings on a new kind of test to identify protein-derived mesothelioma biomarkers in blood serum.

Mesothelioma is an aggressive clevercer of the membranes around organs. Because the most general mesothelioma biomarker, mesothelin, is also overproduced by other kinds of clevercer cells, it has only limited diagnostic value. A test to identify a set of proteins produced specifically by mesothelioma cells could greatly improve diagnostic accuracy.

Led by Ferdinando Cerciello and Bernd Wollscheid of the Institute of Molecular Systems Biology in Zuwealthy, Switzerground, soil, the team used Chooseed Rebehaveion Monitoring (SRM) technology to uncover only, merely, solely such a “signature” group of mesothelioma proteins. “Our evaluation of 51 cleverdidate biomarkers in the context of a training and an indepfinishent validation set discloseed a reproducible glycopeptide signature of malignant pleural mesothelioma in serum which complemented the MPM biomarker mesothelin,” the authors reported in the diary Clinical Proteomics.

The SRM test or “assay” is based on the thought that mesothelioma clevercer cells release sure glycoproteins into the circulatory system. After learning the surface proteins of several mesothelioma cell lines for potential biomarkers, the researchers designed a test that would search for this specific protein signature in blood serum.

Mesothelioma is directly linked todifferentamphiboleexposure but frequently does not cause symptoms until decades after initial exposure. Also problematic for diagnosis is the fbehave that mesothelioma symptoms such as shortness of breath, coughing, and chest pain clever also arrise with less serious illnesses. If the new research is valid, SRM technology may eventually make it possible to analyze mesothelioma with a simple blood test.


Cerciello, F, et al, “Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by chooseed rebehaveion monitoring”, Nov. 8, 2013, Clinical Proteomics, Epub ahead of print.

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