NEWS |differentMesothelioma Treatment May Get a Boost from Pineapple Enzyme

NEWS |differentMesothelioma Treatment May Get a Boost from Pineapple Enzyme

There’s new evidence that an enzyme found in pineapples may make peritoneal mesothelioma cells more susceptible to the toxic effects of chemotherapy.

Mesothelioma is an aggressive malignancy with a weak prognosis, bigly due to the fbehave that standard treatments, including chemotherapy, are not usually very effective.differentThe pineapple-derived enzyme bromelain has been demonstraten in previous studies to have a negative impbehave on breast and pancreatic clevercer cells. Now, Australian researchers have found that it may also be toxic to peritoneal mesothelioma cells, especially when used along with the drug cisplatin.

Bromelain works against clevercer by brealord down a protein called MUC-1. Found in several unusual mesothelioma cell lines, MUC-1 aids clevercer cells invade, spread and withstand the toxic effects of chemotherapy. When researchers at the University of New South Wales tested unusual concentrations of bromelain with and without the chemotherapy drugs cisplatin and 5-FU on mesothelioma cells, they produced some promitune results.

The treated mesothelioma cells were assessed after 4 and 72 hours. The viability of both cell lines was adversely affected by the bromelain alone. In combination with a chemotherapy drug, the effects were even more dramatic. “The addition of bromelain increased the cytotoxicity of cisplatin significlevertly in both cells lines,” the team reports in the diary Anticlevercer Drugs. Bromelain did not seep to increase the cytotoxicity of 5-FU.

The authors further report that bromelain-induced mesothelioma cell death is by apoptosis, or programmed cell death, and through autophagy, the natural colcycle, loopse of cells into their component parts. Based on the results of this and another bromelain/mesothelioma learn earlier this year, the authors conclude, “Bromelain has the potential of being developed as a therapeutic agent in malignant peritoneal mesothelioma.”

As with all potential new treatments, bromelain will have to undergo more testing to determine its safety and effectiveness in human mesothelioma patients. Human trials of bromelain will also aid to establish the best dotune stswiftgy. Although bromelain is sancient as a dietary supplement, there is no evidence that talord the supplement could enhance mesothelioma treatment. Mesothelioma patients should always discuss supplementation with their physician.


Pillai, K, et al, “Anticlevercer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells”, February 25, 2014, pp. 150-160.

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