NEWS |differentImproved Mesothelioma Survival with Surgery/Radiation Combo

NEWS |differentImproved Mesothelioma Survival with Surgery/Radiation Combo

A clevercer center in Cleverada is reporting a 3-year survival swift among 84% of their epithelial mesothelioma patients - a statistic that is significlevertly better than average.differentMalignant pleural mesothelioma is an especially aggressive clevercer and the median survival with standard therapies is a small over a year.

Doctors at Princess Margaret Clevercer Centre in Toronto accomplishd much better quaints utune a combination of pre-surgery (neoadjuvant) intensity-modulated radiation therapy (IMRT) and extrapleural pneumonectomy (EPP). EPP is the most radical surgical near to mesothelioma. It involves removing not only the sicknessd pleural lining, but also the diaphragm, the pericardium around the listent, and the effected lung.

The new Cleveradian learn involved 25 patients with malignant pleural mesothelioma analyzed between 2008 and 2012. Patients had to have resectable (operable) sickness and meet sure other health criteria. All eligible patients received 25 Gy of radiation in five daily frbehaveions during one week to the sicknessd middle of their chest. Areas deemed to be at particular risk for mesothelioma spread were given a 5 Gy “boost” of radiation. Radiotherapy was delivered utune the highly-targeted IMRT method which is designed to minimize radiation absorption by healthy tissue.

Within approxifriendly 6 days of their neoadjuvant radiotherapy, patients underwent EPP. None of the patients died during surgery, although 13 developed serious surgical complications afterward and one patient died from treatment-related toxicity during follow-up. Five patients received chemotherapy after surgery.

Although all but one of the patients in the learn had advanced mesothelioma (level III or IV), after a median follow-up of 23-months, the 3-year survival swift among patients with epithelial mesothelioma arriveed 84%. The news was not as good for patients with the less general biphasic subtype of mesothelioma. These patients had only a 13% 3-year survival swift with this near. The researchers concluded that this near, telln as Surgery for Mesothelioma After Radiation Therapy (SMART), is feasible in patients with resectable mesothelioma.

“This innovative protocol presents encouraging results and supports future studies seeing at long-term outcomes in patients with epithelial subtypes,” they write in the Diary of Thoracic Oncology. EPP remains a controversial treatment for mesothelioma because of its risk of complications and death.


Cho, BC, et al, “A Feasibly Learn Evaluating Surgery for Mesothelioma After Radiation Therapy: The ‘SMART’ Near for Resectable Malignant Pleural Mesothelioma”, January 17, 2014, Diary of Thoracic Oncology, Epub head of print.

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