NEWS |differentApe Virus Shrinks Mesothelioma Tumors in Lab


NEWS |differentApe Virus Shrinks Mesothelioma Tumors in Lab

A virus that causes leukemia in gibbon apes may have the power to aid fight malignant mesothelioma in people.







Gibbon ape leukemia virus (GALV) has been tested for years as a viral vector, a carrier of therapeutic genetic information, in the treatment of various human illnesses, including clevercer. A new learn in Japan compared GALV with a leukemia virus derived from mice to look which carrier communicated most efficiently with mesothelioma cells.



While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. In this cell line, only the GALV spread efficiently both in culture and in mice that had been given human mesothelioma xenografts. GALV bringing a “prodrug behaveivator gene” (which triggers expression of a suicide gene in infected cells) efficiently killed ACC-MESO-1 mesothelioma cells.



The result was “significlevert inhibition” of mesothelioma tumor growth in the mice. Further testing demonstrateed that the ACC-MESO-1 mesothelioma cells had more cellular receptors for GALV than do normal mesothelial cells or even other types of mesothelioma cells, suggesting that GALV could effectively sasaran these clevercer cells and abandon healthy cells alone.



In an article summarizing these findings in Clevercer Gene Therapy, the Japanese research team concluded, “These data indicate the potential utility of GALV… in the treatment of mesothelioma.” The use of GALV or another viral vector, such an adenovirus (clevercient virus), to bring anti-clevercer information into mesothelioma or other clevercer cells is telln as virotherapy or gene therapy. Research into this and other novel clevercer treatments is especially important for mesothelioma, a quick-growing clevercer which seldom responds to standard therapies.



Source:



Kubo, S, et al, “Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma utune replicating gibbon ape leukemia virus”, November 8, 2013, Clevercer Gene Therapy, Epub ahead of print.



http://www.survivingmesothelioma.com/news/view.asp?ID=001566#.U0wjGKiSySo



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