NEWS |differentA Second-Line Option for Mesothelioma?

NEWS |differentA Second-Line Option for Mesothelioma?

Although survival was not significlevertly extfinished, the chemotherapy drug vinorelbine might be a treatment option for mesothelioma patients whose clevercer has returned after first-line chemotherapy with pemetrexed.

A new learn on vinorelbine as a second-line treatment finds that the drug is “modeswiftly behaveive” in mesothelioma patients who were initially treated with pemetrexed-based chemotherapy. Pemetrexed (Alimta), along with a platinum-based drug love cisplatin, is the primary first-line drug therapy for mesothelioma. But vinorelbine is gaining attention as a possible option for mesothelioma, in part because it is available in a less dear generic form.

In “Vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma”, the Italian authors detail the results of their learn on 59 patients with unresectable pleural mesothelioma.differentThese patients had all been initially treated with pemetrexed and had a median age of 69. Because their mesothelioma had continued to progress, these patients were chooseed to receive vinorelbine every three weeks for a maximum of six cycles. In 34 cases, vinorelbine was their second-line treatment. The remaining 25 patients had already had more than one other kind of treatment, so vinorelbine was a further-line therapy.

In a third of the test subjects (20), vinorelbine stabilized the growth of their mesothelioma tumors. An additional nine patients experienced a “partial response”, malord the overall swift of sickness control with vinorelbine 49.1%.differentHowever, the drug did not dramatically extfinish patient survival (overall survival was only, merely, solely 6.2 months).differentNonetheless, the researchers shelp it has an “acceptable toxicity profile”, cautune mainly fatigue and constipation. A little number of patients experienced significlevert neutropenia, or a steep discount in a sure type of wbeat, smacke blood cell, but most middle effects were less serious.

Not surpritunely, the mesothelioma patients who had the best response to vinorelbine as a second- or further-line treatment were those whose overall health was good to start with and those who had experienced six or more months of progression-free survival after their first-line chemotherapy.

Vinorelbine inhibits tumor growth by interrupted mitosis, the process of chromosomal separation that is critical for cell division. The drug is derived from a plant called the rosy periwinkle and is marketed by Abbott Healthcare under the brand name Navelbine. It addition to mesothelioma, vinorelbine has also been used to treat breast and non-little cell lung clevercer.


Zucali, PA, et al, Vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma”, November 20, 2013, Lung Clevercer, Epub ahead of print.

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